Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)

HHS-NIH11 RFA-AI-27-018

Posted: Oct 06, 2026 12:00:00 AM EDT

Closes: 06/20/2029

Funding Information

Estimated Total Funding

$7,000,000

Expected Number of Awards

10

Description

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.

Eligibility

Eligible Applicants:

Independent school districts Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled "Additional Information on Eligibility" for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments City or township governments Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Funding Activity Categories

Health

CFDA Numbers

93.121 - Oral Diseases and Disorders Research
93.233 - National Center on Sleep Disorders Research
93.242 - Mental Health Research Grants
93.273 - Alcohol Research Programs
93.279 - Drug Use and Addiction Research Programs
93.307 - Minority Health and Health Disparities Research
93.310 - Trans-NIH Research Support
93.313 - NIH Office of Research on Women's Health
93.361 - Nursing Research
93.393 - Cancer Cause and Prevention Research
93.394 - Cancer Detection and Diagnosis Research
93.399 - Cancer Control
93.837 - Cardiovascular Diseases Research
93.838 - Lung Diseases Research
93.839 - Blood Diseases and Resources Research
93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
93.846 - Arthritis, Musculoskeletal and Skin Diseases Research
93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research
93.855 - Allergy and Infectious Diseases Research
93.865 - Child Health and Human Development Extramural Research
93.866 - Aging Research
93.879 - Medical Library Assistance

Contact Information

Agency: National Institutes of Health

Contact: National Institutes of Health

Email: OD-OARHIVISRFA27-018@nih.gov

Phone: 301-402-2541

National Institute of Allergy and Infectious Diseases (NIAID)
OD-OARHIVISRFA27-018@nih.gov

Additional Information

Document Type: synopsis

Opportunity Category: Discretionary

Version: 2

Last Updated: Oct 06, 2026 04:01:03 PM EDT

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